Best weight loss treatment UK available through the NHS and private clinics. GLP-1 medications like Wegovy (semaglutide) and Mounjaro (tirzepatide) are approved for weight management, especially for individuals with a BMI of 35 or higher, or 30 with related health conditions. These treatments suppress appetite and improve metabolic health. Orlistat (Xenical) is another option, available both on prescription and over the counter, which reduces fat absorption. Eligibility for NHS prescriptions requires a referral to a specialist weight management service. For those seeking alternatives, private clinics offer medications like Mysimba and Synt-101, a new daily pill showing promise with minimal side effects. Consultation with a healthcare provider is essential to determine the most suitable treatment plan.